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Lopinavir 200mg, Ritonavir 50mg


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Brand Generic Brand  
Product ID 8699548093692
Product Kaletra 200mg/50mg
Strength 200mg/50mg
Pack Size 120
Pharmaceutical Form Tablets
Active Ingredients Lopinavir / Ritonavir
Manufacturer Abbott
License Holder Abbott
E.Q.US.Brand Name Kaletra
Origin Germany
Active-Passive-Not Avaliable Active

Why is this medication prescribed?

The combination of lopinavir and ritonavir is used with other medications to treat human immunodeficiency virus (HIV) infection. Lopinavir and ritonavir are in a class of medications called protease inhibitors. They work by decreasing the amount of HIV in the blood. When lopinavir and ritonavir are taken together, ritonavir also helps to increase the amount of lopinavir in the body so that the medication will have a greater effect. Although lopinavir and ritonavir will not cure HIV, these medications may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting the HIV virus to other people.

How should this medicine be used?

The combination of lopinavir and ritonavir comes as a tablet and a solution (liquid) to take by mouth. It is usually taken twice a day, but may be taken once a day by certain adults. The solution must be taken with food. The tablets may be taken with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lopinavir and ritonavir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

If you are using the solution, shake it well before each use to mix the medication evenly. Use a dose-measuring spoon or cup to measure the correct amount of liquid for each dose, not a regular household spoon.

Continue to take lopinavir and ritonavir even if you feel well. Do not stop taking lopinavir and ritonavir without talking to your doctor. If you miss doses, take less than the prescribed amount, or stop taking lopinavir and ritonavir, your condition may become more difficult to treat.

Other uses for this medicine


This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?


Before taking lopinavir and ritonavir,

  • tell      your doctor and pharmacist if you are allergic to lopinavir, ritonavir      (Norvir), any other medications, or any of the ingredients in lopinavir      and ritonavir tablets or solution. Ask your pharmacist for a list of the      ingredients.
  • tell      your doctor if you are taking any of the following medications: alfuzosin      (Uroxatral); cisapride (Propulsid) (not available in the U.S.); ergot      medications such as dihydroergotamine (D.H.E. 45, Migranal), ergonovine,      ergotamine (Ergomar, in Cafergot, in Migergot), and methylergonovine      (Methergine); lovastatin (Altoprev, Mevacor, in Advicor); midazolam      (Versed); pimozide (Orap); rifampin (Rimactane, Rifadin, in Rifamate, in      Rifater); sildenafil (only Revatio brand used for lung disease);      simvastatin (Simcor, Zocor, in Vytorin); or triazolam (Halcion). Your      doctor will probably tell you not to take lopinavir and ritonavir if you      are taking one or more of these medications.
  • tell      your doctor and pharmacist what other prescription and nonprescription      medications, vitamins, and nutritional supplements you are taking. Be sure      to mention any of the following: anticoagulants ('blood thinners') such as      warfarin (Coumadin); antifungals such as itraconazole (Sporanox),      ketoconazole (Nizoral), and voriconazole (Vfend); atovaquone (Mepron, in      Malarone); beta-blockers; boceprevir (Victrelis); bosentan (Tracleer);      bupropion (Wellbutrin, Zyban); calcium-channel blockers such as      felodipine, nicardipine (Cardene), and nifedipine (Adalat, Procardia);      cholesterol-lowering medications such as atorvastatin (Lipitor), and      rosuvastatin (Crestor); clarithromycin (Biaxin); colchicine (Colcrys);      digoxin (Lanoxin); fentanyl (Actiq, Duragesic, Onsolis); fluticasone      (Advair, in Flovent); fosamprenavir (Lexiva); certain medications for      cancer such as dasatinib (Sprycel), nilotinib (Tasigna). vinblastine, and      vincristine; certain medications for irregular heartbeat such as      amiodarone (Cordarone, Pacerone), lidocaine, and quinidine (Quinidex);      certain medications for seizures such as carbamazepine (Equetro, Tegretol),      phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin); medications      that suppress the immune system such as cyclosporine (Neoral, Sandimmune),      sirolimus (Rapamune), and tacrolimus (Prograf); methadone (Dolophine);      oral steroids such as dexamethasone (Decadron, Dexone); other antiviral      medications such as abacavir (Ziagen, in Epzicom, in Trizivir); atazanavir      (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), indinavir      (Crixivan), maraviroc (Selzentry), nelfinavir (Viracept), nevirapine (Viramune),      ritonavir (Norvir), tenofovir (Viread, in Atripla, in Truvada), tipranavir      (Aptivus),saquinavir (Invirase), and zidovudine (Retrovir, in Combivir, in      Trizivir); rifabutin (Mycobutin); salmeterol (Serevent, in Advair);      sildenafil (Viagra); tadalafil (Adcirca, Cialis); trazodone (Oleptro) and      vardenafil (Levitra). If you are taking the oral solution, also tell your      doctor if you are taking disulfiram (Antabuse) or metronidazole (Flagyl).      Your doctor may need to change the doses of your medications or monitor      you carefully for side effects.
  • if      you are taking didanosine, take it 1 hour before or 2 hours after you take      lopinavir and ritonavir solution with food. If you are taking lopinavir      and ritonavir tablets, you may take them on an empty stomach at the same      time as you take didanosine.
  • tell      your doctor what herbal products you are taking, especially products      containing St. John's wort. You should not take St. John's wort during      your treatment with lopinavir and ritonavir.
  • tell      your doctor if you have or have ever had a prolonged QT interval (a rare      heart problem that may cause irregular heartbeat, fainting, or sudden      death), an irregular heartbeat, a low level of potassium in your blood,      hemophilia, high cholesterol or triglycerides (fat) in the blood,      pancreatitis (swelling of the pancreas), or heart or liver disease.
  • you      should know that lopinavir and ritonavir may decrease the effectiveness of      hormonal contraceptives (birth control pills, patches, rings, or      injections). Talk to your doctor about using another form of birth      control.
  • tell      your doctor if you are pregnant, plan to become pregnant, or are      breast-feeding. If you become pregnant while taking lopinavir and      ritonavir, call your doctor. You should not breast-feed if you are      infected with HIV or if you are taking lopinavir and ritonavir.
  • you      should know that certain ingredients in lopinavir and ritonavir solution      may cause serious and life-threatening side effects in newborn babies.      Lopinavir and ritonavir oral solution should not be given to full-term      babies younger than 14 days old or to premature babies younger than 14      days past their original due date, unless a doctor thinks there is a good      reason for the baby to receive the medication right after birth. If your      baby's doctor chooses to give your baby lopinavir and ritonavir solution      immediately after birth, your baby will be monitored carefully for signs      of serious side effects. Call your baby's doctor immediately if your baby      is very sleepy or has changes in breathing during his or her treatment      with lopinavir and ritonavir oral solution.
  • you      should be aware that your body fat may increase or move to different areas      of your body, such as your upper back, neck (''buffalo hump''), breasts,      and around your stomach. You may notice a loss of body fat from your face,      legs, and arms.
  • you      should know that you may experience hyperglycemia (increases in your blood      sugar) while you are taking this medication, even if you do not already      have diabetes. Tell your doctor immediately if you have any of the following      symptoms while you are taking lopinavir and ritonavir: extreme thirst,      frequent urination, extreme hunger, blurred vision, or weakness. It is      very important to call your doctor as soon as you have any of these      symptoms, because high blood sugar that is not treated can cause a serious      condition called ketoacidosis. Ketoacidosis may become life-threatening if      it is not treated at an early stage. Symptoms of ketoacidosis include: dry      mouth, nausea and vomiting, shortness of breath, breath that smells fruity,      and decreased consciousness.
  • you      should know that while you are taking medications to treat HIV infection,      your immune system may get stronger and begin to fight other infections      that were already in your body. This may cause you to develop symptoms of      those infections. If you have new or worsening symptoms after starting      treatment with lopinavir and ritonavir, be sure to tell your doctor.

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